MELATONINA:
Fanjul-Moles ML et al: Relationship between Oxidative Stress, Circadian Rhythms, and AMD. Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 7420637 [Full PDF] Nandrot F et al: Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking alfavbeta5 Integrin. J. Exp. Med. Volume 200, Number 12, December 20, 2004 1539–1545 [Full PDF] Laurent V. et al.: Melatonin signaling affects the timing in the daily rhythm of phagocytic activity by the retinal pigment epithelium. Exp Eye Res. 2017 December; 165: 90–95 [Full PDF] Lv XD. et al. Correlation between serum melatonin and aMT6S level for age-related macular degeneration patients. Eur Rev Med Pharmacol Sci. 2016 Oct;20(20):4196-4201 [Full PDF] Schmid-Kubista KE et al. Daytime levels of melatonin in patients with age-related macular degeneration. Acta Ophthalmol. 2009: 87: 89–93 [Full PDF] Chang CC et al. Protective Effect of Melatonin against Oxidative Stress-Induced Apoptosis and Enhanced Autophagy in Human Retinal Pigment Epithelium Cells. Oxidative Medicine and Cellular Longevity Volume 2018, Article ID 9015765 [Full PDF] Blasiak J. Et al. Melatonin in Retinal Physiology and Pathology: The Case of Age-Related Macular Degeneration. Oxid Med Cell Longev. 2016; 2016:6819736 [Full PDF] Tosini G. et al. Melatonin: An Underappreciated Player in Retinal Physiology and Pathophysiology. Exp Eye Res. 2012 October ; 103: 82–89 [Full PDF] Skene DJ et al. Circadian rhythm sleep disorders in the blind and their treatment with melatonin. Sleep Medicine 8 (2007) 651–655 [Only abstract] Brown EE et al. Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors. Redox Biology 24 (2019) 1012 [Full PDF] Hardeland R. Aging, Melatonin, and the Pro- and Anti-Inflammatory Networks. Int J Mol Sci. 2019 Mar 11; 20(5): 1223 [Full PDF]VITAMINA D3:
Tohari AM, Alhasani RH, Biswas L, Patnaik SR, Reilly J, Zeng Z, Shu X. Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells. Antioxidants (Basel). 2019 Aug 24;8(9). pii: E341 [Full PDF] Kaarniranta K, Pawlowska E, Szczepanska J, Jablkowska A, Błasiak J. Can vitamin D protect against age-related macular degeneration or slow its progression? Acta Biochim Pol. 2019 Jun 18;66(2):147-158 [Full PDF] Millen AE, Nie J, Mares JA, Lutsey PL, LaMonte MJ, Meuer SM, Sahli MW, Andrews CA, Klein BEK, Klein R. Serum 25-Hydroxyvitamin D Concentrations and Incidence of Age-Related Macular Degeneration: The Atherosclerosis Risk in Communities Study. Invest Ophtha Invest Ophthalmol Vis Sci. 2019;60:1362–1371. https://doi.org/ 10.1167/iovs.18-25945 [Full PDF] Hashemi R, Bandarian M, Abedi-Taleb E, Khojasteh H, Khedmat L, Asadollahi E, Beytollahi M, Jelodar AM The association between blood vitamins D and E with age-related macular degeneration: A pilot study. Interv Med Appl Sci. 2018 Sep;10(3):127-132 [Full PDF] Skowron K, Pawlicka I, Gil K. The role of vitamin D in the pathogenesis of ocular diseases. Folia Med Cracov. 2018;58(2):103-118 [Full PDF] Layana AG, Minnella AM, Garhöfer G, Aslam T, Holz FG, Leys A, Silva R, Delcourt C, Souied E, Seddon JM. Vitamin D and Age-Related Macular Degeneration. Nutrients. 2017 Oct 13;9(10) [Full PDF] Merle BMJ, Silver RE, Rosner B, Seddon JM Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration. Invest Ophthalmol Vis Sci. 2017 Sep 1;58(11):4569-4578 [Full PDF] Gareth J McKay, Ian S Young, Ann McGinty, Graham C G Bentham, Usha Chakravarthy, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Jesus Vioque, Paulus T V M de Jong, Astrid E Fletcher.Associations between Serum Vitamin D and Genetic Variants in Vitamin D Pathways and Age-Related Macular Degeneration in the European Eye Study. Ophthalmology. 2017 Jan;124(1):90-96 [Full PDF] Wu W, Weng Y, Guo X, Feng L, Xia H, Jiang Z, Lou J. The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review. Invest Ophthalmol Vis Sci. 2016 Apr 1;57(4):2168-77 [Full PDF] Annweiler C, Drouet M, Duval GT, Paré PY, Leruez S, Dinomais M, Milea D. Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis. Maturitas. 2016 Jun; 88:101-12 [Only abstract]ASTAXANTINA:
Küçüködük A, Helvacioglu F, Haberal N, Dagdeviren A, Bacanli D, Yilmaz G, Akkoyun I. Antiproliferative and anti-apoptotic effect of astaxanthin in an oxygen-induced retinopathy mouse model. Can J Ophthalmol. 2019 Feb;54(1):65-74 [Only abstract] Inoue Y, Shimazawa M, Nagano R, Kuse Y, Takahashi K, Tsuruma K, Hayashi M, Ishibashi T, Maoka T, Hara H. Astaxanthin analogs, adonixanthin and lycopene, activate Nrf2 to prevent light-induced photoreceptor degeneration. J Pharmacol Sci. 2017 Jul;134(3):14 [Full PDF] Otsuka T, Shimazawa M, Inoue Y, Nakano Y, Ojino K, Izawa H, Tsuruma K, Ishibashi T, Hara H. Astaxanthin Protects Against Retinal Damage: Evidence from In Vivo and In Vitro Retinal Ischemia and Reperfusion Models. Curr Eye Res. 2016 Nov;41(11):1465-1472 [Only abstract] Yeh PT, Huang HW, Yang CM, Yang WS, Yang CH. Astaxanthin Inhibits Expression of Retinal Oxidative Stress and Inflammatory Mediators in Streptozotocin-Induced Diabetic Rats. PLoS One. 2016 Jan 14;11(1):e 0146438 [Full PDF] Yamagishi R, Aihara M. Neuroprotective effect of astaxanthin against rat retinal ganglion cell death under various stresses that induce apoptosis and necrosis. Mol Vis. 2014 Dec 31; 20:1796-805 [Full PDF] Otsuka T, Shimazawa M, Nakanishi T, Ohno Y, Inoue Y, Tsuruma K, Ishibashi T, Hara H. Protective effects of a dietary carotenoid, astaxanthin, against light-induced retinal damage. J Pharmacol Sci. 2013;123(3):209-18 [Full PDF] Saito M, Yoshida K, Saito W, Fujiya A, Ohgami K, Kitaichi N, Tsukahara H, Ishida S, Ohno S. Astaxanthin increases choroidal blood flow velocity. Graefes Arch Clin Exp Ophthalmol. 2012 Feb;250(2):239-45 [Only abstract] Piermarocchi S, Saviano S, Parisi V, Tedeschi M, Panozzo G, Scarpa G, Boschi G, Lo Giudice G; Carmis Study Group. Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study. Eur J Ophthalmol. 2012 Mar-Apr;22(2):2 [Only abstract] Parisi V., Tedeschi M, Gallinaro G, Varano M, Saviano S., Piermarocchi S., Carotenoids and antioxidants in age-related maculopathy italian study: multifocal electroretinogram modifications after 1 year Ophthalmology 115(2) (2008) 324-333. e2 [Only abstract] Ohgami K et al, Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation in Vitro and in Vivo Invest Ophthalmol Vis Sci 44 (6), 2694-701 Jun 2003 [Full PDF]POLIDATINA:
Qiao H, Chen H, Dong Y, Ma H, Zhao G, Tang F, Li Z. Polydatin Attenuates H2O2-Induced Oxidative Stress via PKC Pathway. Oxid Med Cell Longev. 2016; 2016:5139458 [Full PDF] Wang HL, Gao JP, Han YL, Xu X, Wu R, Gao Y, Cui XH. Comparative studies of polydatin and resveratrol on mutual transformation and antioxidative effect in vivo. Phytomedicine. 2015 May 15;22(5):553-9 [Only abstract] Du QH, Peng C, Zhang H. Polydatin: a review of pharmacology and pharmacokinetics. Pharm Biol. 2013 Nov;51(11):1347-54 [Full PDF] Su D, Cheng Y, Liu M, Liu D, Cui H, Zhang B, Zhou S, Yang T, Mei Q. Comparision of piceid and resveratrol in antioxidation and antiproliferation activities in vitro. PLoS One. 2013;8(1):e54505 [Full PDF] Ravagnan G, De Filippis A, Cartenì M, De Maria S, Cozza V, Petrazzuolo M, Tufano MA, Donnarumma G. Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response. Inflammation. 2013 Feb;36(1):26-34 [Only abstract]COENZIMA Q10:
Ju WK, Shim MS, Kim KY, Bu JH, Park TL, Ahn S, Weinreb RN. Ubiquinol promotes retinal ganglion cell survival and blocks the apoptotic pathway in ischemic retinal degeneration. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2639-2645 [Full PDF] Zhang X, Tohari AM, Marcheggiani F, Zhou X, Reilly J, Tiano L, Shu X. Therapeutic Potential of Co-enzyme Q10 in Retinal Diseases. Curr Med Chem. 2017;24(39):4329-4339 [Only abstract] Qu J, Kaufman Y, Washington I. Coenzyme Q10 in the human retina. Invest Ophthalmol Vis Sci. 2009 Apr;50(4):1814-8 [Full PDF] Feher J, Kovacs B, Kovacs I, Schveoller M, Papale A, Balacco Gabrieli C. Improvement of visual functions and fundus alterations in early age-related macular degeneration treated with a combination of acetyl-L-carnitine, n-3 fatty acids, and coenzyme Q10 [Only abstract] Blasi MA, Bovina C, Carella G, Genova ML, Jansen AM, Lenaz G, Brancato R. Does coenzyme Q10 play a role in opposing oxidative stress in patients with age-related macular degeneration? Ophthalmologica. 2001 Jan-Feb;215(1):51-4 [Only abstract]ACIDO ALFA LIPOICO:
Tao Y, Jiang P, Wei Y, Wang P, Sun X, Wang H. α-Lipoic Acid Treatment Improves Vision-Related Quality of Life in Patients with Dry Age-Related Macular Degeneration. Tohoku J Exp Med. 2016 Nov;240(3):209-214 [Full PDF] Sun YD, Dong YD, Fan R, Zhai LL, Bai YL, Jia LH. Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration. Ann Nutr Metab. 2012;60(4):293-7 [Only abstract] Sarezky D, Raquib AR, Dunaief JL, Kim BJ. Tolerability in the elderly population of high-dose alpha lipoic acid: a potential antioxidant therapy for the eye. Clin Ophthalmol. 2016 Sep 29; 10:1899-1903 [Full PDF]LUTEINA:
Karakurt Y, Süleyman H, Keskin Cimen F, Tasli G, Ucak T, Icel E, Kurt N. The Effects of Lutein on Optic Nerve Injury Induced By Ethambutol and Isoniazid: An Experimental Study. Cutan Ocul Toxicol. 2018 Oct 26:1-13. doi: 10.1080/15569527.2018.1539010 [Only abstract] Chae SY, Park SY, Park G. Lutein protects human retinal pigment epithelial cells from oxidative stress‑induced cellular senescence. Mol Med Rep. 2018 Oct 8 [Full PDF] Kumari N, Cher J, Chua E, Hamzah H, Wong TY, Cheung CY. Association of serum lutein and zeaxanthin with quantitative measures of retinal vascular parameters. PLoS One. 2018 Sep 27;13(9):e0203868. doi: 10.1371/journal.pone.0203868. eCollection 2018 [Full PDF]ZINCO:
Gilbert R, Peto T, Lengyel I, Emri E. Zinc Nutrition and Inflammation in the Aging Retina. Mol Nutr Food Res. 2019 Aug;63(15):e1801049 [Full PDF] Rodríguez-Menéndez S, García M, Fernández B, Álvarez L, Fernández-Vega-Cueto A, Coca-Prados M, Pereiro R, González-Iglesias H. The Zinc-Metallothionein Redox System Reduces Oxidative Stress in Retinal Pigment Epithelial Cells. Nutrients. 2018 Dec 2;10(12) [Full PDF] Pao PJ, Emri E, Abdirahman SB, Soorma T, Zeng HH, Hauck SM, Thompson RB, Lengyel I. The effects of zinc supplementation on primary human retinal pigment epithelium. J Trace Elem Med Biol. 2018 Sep;49:184-191 [Only abstract] Rajapakse D, Curtis T, Chen M, Xu H. Zinc Protects Oxidative Stress-Induced RPE Death by Reducing Mitochondrial Damage and Preventing Lysosome Rupture. Oxid Med Cell Longev. 2017;2017:6926485 [Full PDF] Smailhodzic D, van Asten F, Blom AM, Mohlin FC, den Hollander AI, van de Ven JP, van Huet RA, Groenewoud JM, Tian Y, Berendschot TT, Lechanteur YT, Fauser S, de Bruijn C, Daha MR, van der Wilt GJ, Hoyng CB, Klevering BJ.Zinc supplementation inhibits complement activation in age-related macular degeneration. PLoS One. 2014 Nov 13;9(11):e112682 [Full PDF] Ripps H, Chappell RL. Review: Zinc’s functional significance in the vertebrate retina. Mol Vis. 2014 Jul 31;20:1067-74 [Full PDF] Julien S, Biesemeier A, Kokkinou D, Eibl O, Schraermeyer U. Zinc deficiency leads to lipofuscin accumulation in the retinal pigment epithelium of pigmented rats. PLoS One. 2011;6(12):e29245 [Full PDF] *I link portano ad indirizzi web di editori o banche dati, che hanno deciso di offrire la lettura di tali articoli in PDF a titolo gratuito. Pertanto nessuna violazione del copyright può essere imputata ad Oftagest S.r.l. L’editore potrebbe variare a suo insindacabile giudizio le modalità di visualizzazione degli articoli. Qualora si decidesse di scaricare uno o più articoli in PDF, la diffusione ad altre persone o su piattaforme online potrebbe rappresentare una violazione dei diritti di copyright. Si consiglia di leggere preventivamente sul sito dell’editore o sull’articolo stesso le normative vigenti in tema di diffusione dell’opera. Tutti i link sono stati verificati ed il contenuto scaricato è stato verificato con programmi idonei a garantirne la sicurezza.